Our Strategy

Our proprietary product engine focuses on dysregulated transcription factors and the transcriptional regulatory networks (TRNs) through which they drive oncogenic activity. Our lead product candidate, entospletinib (ENTO), is an investigational spleen tyrosine kinase (SYK) inhibitor being developed for the frontline treatment of NPM1-mutated acute myeloid leukemia (AML). We plan to initiate a registrational Phase 3 trial in this population in mid-2021 to support ENTO’s potential accelerated approval. We are also developing KB-0742, a selective, orally bioavailable inhibitor of cyclin dependent kinase 9 (CDK9) for the treatment of MYC-amplified solid tumors. We have initiated a Phase 1/2 trial for KB-0742 and expect to report initial safety, PK and PD data from the dose escalation cohorts in the fourth quarter of 2021. In addition, we have multiple oncology discovery programs targeting dysregulated transcription factors.

Our Science:

Targeting dysregulated transcription factors in cancer

Addressing the complexity of oncogenic TRNs requires a sophisticated and holistic approach to targeting cancer biology. TRNs encompass hundreds of proteins that function in a coordinated fashion to orchestrate specific gene expression programs that control development and function of healthy cells. Dysregulated TRNs resulting from aberrant transcription factor expression or activity are frequently responsible for reprogramming healthy cells into cancerous tumor cells. We apply computational biology to map the TRNs and identify the critical nodes and gene expression signatures that drive cancer. We believe that these critical nodes present attractive targets for therapeutic intervention using a biomarker-driven precision medicine strategy.

Product Engine

Our product engine includes four interconnected components, each of which is informed by our translational expertise, that enable efficient, hypothesis-driven clinical development of our product candidates:

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Identify gene expression signature of selective TRN modulation

Conduct high throughput SMM screens in tumor cell lysates to identify selective TRN modulators

Refine pharmacological properties to yield attractive product development candidates

Hypothesis driven clinical trials to deliver proof of concept early in the development process

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Identify gene expression signature of selective TRN modulation​

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Conduct high throughput SMM screens in tumor cell lysates to identify selective TRN modulators

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Refine pharmacological properties to yield attractive development candidates

validate

Hypothesis driven clinical trials to deliver proof of concept early in the development process

Pipeline/Programs

We have developed a robust clinical and preclinical pipeline through a combination of internal discovery efforts and focused asset acquisition. The following chart summarizes our product pipeline, including our lead product candidate, ENTO, as well as our discovery programs and our next anticipated milestones.

Product Candidate

Discovery

IND-Enabling Studies

Phase 1 Trial

Phase 2 Trial

Phase 3 Trial

Next Anticipated Milestone

Mid-2021: Initiate NPM1 mt AML registrational Phase 3 clinical trial

2021: Initiate FLT3 mt AML Phase 1/2 clinical trial in combination with a FLT3 inhibitor

Q4 2021: Initial safety, PK and PD data from dose escalation cohorts

TRN

Indication

Discovery

IND-Enabling Studies

Phase 1 Trial

Phase 2 Trial

Phase 3 Trial

Next Anticipated Milestone

MYB

AML

First IND filing in 2022 among these programs

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Prostate Cancer

IRF4

Multiple Myeloma

ASCL1

Small Cell / Neuroendocrine Cancers

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Careers

JOIN OUR TEAM

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We are looking for innovative team members who share our passion for transformative science paired with unparalleled execution.

See our current list of openings below or submit your resume to careers@kronosbio.com.

we’re building the highway, not filling potholes”

‟we’re building the highway, not filling potholes”

marius_pop
Marius Pop
Director, Biology