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DISCOVER
  • First-in-class or highly differentiated agents
  • Against challenging targets with a well-characterized role in cancer
DEVELOP
  • For clearly defined populations with high unmet need
  • Via accelerated approval pathways (breakthrough or orphan designation)
COMMERCIALIZE
  • With focused infrastructure to support product launches in targeted indications

Pursuing therapies against some of the most intractable cancer targets

Kronos Bio is dedicated to the discovery and development of first-in-class therapies that modulate historically undruggable targets. We leverage deep capabilities in high-throughput small molecule microarrays (SMM), targeted protein degradation, and cancer biology in order to identify potent and selective compounds against transcription factors and other central drivers of oncogenic signaling.

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Our Science

Despite significant progress over the past few decades in developing small molecule therapeutics against drug targets with clearly defined binding sites, the majority of potential targets in human disease do not fit current models of drug discovery. Well-known oncogenic targets such as MYC and ARv7 that function as transcriptional drivers or through other protein-protein interactions are often poorly suited to traditional high-throughput screening or rational design. The targets are frequently disordered when isolated from binding partners or physiological complexes, generally lack obvious binding pockets, and may act through complex signaling pathways. Despite a wealth of data implicating these oncogenes in some of the deadliest forms of cancer, no approved therapeutics exist. Thus, there is a critical need for new approaches to discover drug candidates against these targets.

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Targeted Protein Degradation
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publications

Small Molecule Microarray

Targeted Protein Degradation

Pipeline/
Programs

Publications

small molecule microarray icon

Small Molecule Microarray

Targeted Protein Degradation

Targeted Protein Degradation

pipeline-icon

Pipeline/
Programs

publications

Publications

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Careers

JOIN OUR TEAM

We are looking for innovative team members who share our passion for transformative science paired with unparalleled execution.

See our current list of openings below or submit your resume to careers@kronosbio.com.

we’re building the highway, not filling potholes”

‟we’re building the highway, not filling potholes”

Marius Pop

Director, Biology