Principal Research Scientist/Team Lead

Location: Cambridge, MA


Kronos Bio seeks a highly motivated Principal Research Scientist to join its chemistry team located in Cambridge, MA. As a member of the discovery/medicinal chemistry team, this individual will contribute to the establishment of a proprietary compound library through traditional and parallel synthesis and optimize hits and lead series toward a drug candidate. The Scientist will be responsible for independently developing and implementing medicinal chemistry strategies that effectively surmount complex research problems and facilitate the achievement of key corporate goals – on time and on budget. This individual will act as chemistry project leader for a new project and manage CRO-based chemists, while maintaining close interactions with computer assisted design scientists, biologists, pharmacologists, and pharmaceutical development scientists. The applicant is expected to have strong experimental skills, good communication ability, eagerness for learning, and contribute to a strong culture of teamwork and collaboration.


  • Responsible for communicating project updates to management team, internal colleagues and external collaborators.
  • Coordination of project activities with other disciplines including structural biology, target compound profiling, biology and pharmacology.
  • Seize opportunities to pursue project relevant leads that are in line with the group’s strategy, and be responsible for developing new SAR/series.
  • Design analogues and direct a small team of CRO based medicinal chemists in the synthesis of analogues.
  • Ensure quality of work and data generated.
  • Troubleshoot synthetic schemes as needed.
  • Manage timelines for deliverables.
  • Facilitate communications between chemists and serve as the primary point of contact with the CRO.
  • Independently execute syntheses of target compounds.
  • Independently extend existing synthetic routes.
  • Be able to understand failed reactions and propose modifications.
  • Understand and apply knowledge of the chemical and biological issues affecting the project.
  • Contribute new ideas to the project team.
  • Utilize literature searches to solve specific research problems.


  • PhD with 5+ years industry experience in pharmaceutical hit-to-lead optimization.
  • Management of external / CRO driven medicinal chemistry campaigns.
  • Simultaneously balance multiple tasks.
  • Show initiative to expand scope and depth of technical competence.
  • Act as technical resource in a defined area.
  • Independently plan work to support team and project objectives.
  • Work together with other members of a project team to accomplish team objectives.
  • Demonstrate resiliency and flexibility when confronted with programmatic changes and/or new scientific directions.
  • Ability to clearly communicate ideas and research results.
  • Willingness to perform tasks outside applicant’s area of expertise.
  • Embodies Kronos values; exhibits high degree of integrity and professionalism when interacting with outside investigators and vendors.
  • Entrepreneurial and enjoys working in a fast-paced, creative and resourceful small company environment.

To apply for this position, please forward your resume and cover letter to