Kronos Bio seeks a highly motivated Principal Research Scientist to join its chemistry team located in Cambridge, MA. As a member of the discovery/medicinal chemistry team, this individual will contribute to the establishment of a proprietary compound library through traditional and parallel synthesis and optimize hits and lead series toward a drug candidate. The Scientist will be responsible for independently developing and implementing medicinal chemistry strategies that effectively surmount complex research problems and facilitate the achievement of key corporate goals – on time and on budget. This individual will act as chemistry project leader for a new project and manage CRO-based chemists, while maintaining close interactions with computer assisted design scientists, biologists, pharmacologists, and pharmaceutical development scientists. The applicant is expected to have strong experimental skills, good communication ability, eagerness for learning, and contribute to a strong culture of teamwork and collaboration.