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Open Positions

Proteomics & Mass Spectrometry, Research Scientist

Location: Cambridge, MA

POSITION

Kronos Bio seeks an enthusiastic, experienced analytical scientist to join our Proteomics Group. As a member of an interdisciplinary team, this individual will be expected to employ multiple quantitative proteomics approaches to generate high-quality data to support multiple drug discovery programs. The applicant is expected to have a robust experimental skill set, an eagerness for learning, and contribute to a strong culture of teamwork and collaboration in a fast-paced environment.

ESSENTIAL FUNCTIONS AND DUTIES

Perform deep proteome profiling studies to support target identification / deconvolution, target engagement, and mode-of-action (MOA) elucidation efforts in multiple drug discovery programs.
Contribute to developing and implementing innovative structure and chemical proteomic approaches to investigate protein-ligand interactions.
Responsible for the maintenance, quality control and troubleshooting of multiple proteomics instruments.
Prepare samples from complex biological matrices for LC-MS analysis.
Design and execute experiments independently; accurately record, analyze and present.

SKILLS AND EXPERIENCE

Ph.D. in Analytical Chemistry, Biochemistry, or related discipline with 2+ years of relevant experience.
Expertise in mass-spectrometry-based proteomics, including experiences within some of the following key areas: quantitative proteomics (TMT, SILAC, LFQ), post-translational modification characterization, and chemoproteomics.
Minimum of 5 years hands-on experience in maintaining and troubleshooting nano LC-MS instrument required, ideally Thermo Orbitrap-based MS systems.
Experience in isolating protein from complex biological samples and sample processing workflow for LC-MS analysis.
Experience in analyzing and interpreting LC-MS/MS data using custom, public, and commercially available software suites (Proteome Discover, MaxQuant).
Ability to plan and troubleshoot experiments independently.
Attention to detail and strong record-keeping skills.
Excellent written and oral communication skills.
Flexibility to rapidly adapt workplans to changing priorities and deadlines.
Proven track record of productive bench science with a strong publication record.
Experience in multi-dimensional LC fractionation is desirable.
Experience using HDX-MS or other methods to investigate ligand-protein and protein-protein interactions is desirable.
Experience with immuno- or chemical-affinity enrichment to selectively enrich proteins and chemical biology techniques such as photoaffinity labeling is desirable.
Embodies Kronos values; exhibits high degree of integrity and professionalism when interacting with outside investigators and vendors.
Entrepreneurial and enjoys working in a fast-paced, creative and resourceful small company environment.

To apply for this position, please forward your resume and cover letter to careers@kronosbio.com.

Careers

Open Positions

Proteomics & Mass Spectrometry, Research Scientist

POSITION

ESSENTIAL FUNCTIONS AND DUTIES

SKILLS AND EXPERIENCE

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