Careers

Research Scientist, Drug Discovery – Cancer Biology

Location: Cambridge, MA

POSITION

Kronos Bio seeks a highly motivated Research Scientist to join its drug discovery team located in Cambridge, MA. As a member of an interdisciplinary team, this individual is expected to harness their substantial oncology background to help guide strategic scientific decisions and research program development. The applicant is expected to have a robust experimental skillset, an eagerness for learning, and contribute to a strong culture of teamwork and collaboration in a fast-paced environment.

ESSENTIAL FUNCTIONS AND DUTIES

  • Coordinate with R&D team members to lead key elements of discovery and preclinical development programs for novel cancer therapies.
  • Independently design, optimize and execute various assay formats such as cell-based bioassays (DualGlo, CTGlo, HTRF, HIiBiT, ELISA, CaspaseGlo, 3D cultures) in multiple plate formats.
  • Use a repertoire of protein biochemistry assays (WB, ICW, IP, IHC, pull-down) to clearly define the MOA of novel molecules.
  • Identify cell lines relevant to targets and indication of interest and develop cell-based assays
  • Design, create and validate screening cell lines models using CRISPR or lentiviral technology.
  • Experience with transfection, transduction and electroporation technics for primary cell lines or difficult cell line models
  • Use literature survey to solve specific research problems.
  • Learn and implement new experimental techniques that can answer critical scientific questions and advance programs.
  • Manage and direct external resources (CRO) and collaborators.
  • Actively contribute to a focused, team-oriented atmosphere providing assistance and/or guidance to colleagues when needed.
  • Identify and implement scientific and logistical solutions in a multidisciplinary environment.
  • Maintain high standards of laboratory safety, comply with the safety manual and complete required training courses.
  • Perform research in compliance with all applicable regulatory and guidelines, as informed by supervisor.

SKILLS AND EXPERIENCE

  • PhD or MS/BS in Biology with a minimum of 2 years (PhD) or 6 years (MS/BS) industry/biotech experience
  • Ability to work independently and able to balance multiple tasks or projects.
  • Diligent with details and timely execution and delivery of high-quality results.
  • Strong background in basic research or translational research in oncology, including but not limited to high throughput screening, cell-based assays, molecular biology and protein chemistry.
  • Familiarity with analysis of genomic and gene expression data sets.
  • Experience working with CROs and/or compound management organizations preferred.
  • Highly analytical mind, attention to detail, organization skills, and rigorous experimental record keeping using an ELN system are critical.
  • Collaborative, proactive and optimistic personality.

To apply for this position, please forward your resume and cover letter to careers@kronosbio.com.